105 Rationale for HIV vaccines design

The rationale for quadrivalent influenza vaccines

Two antigenically distinct lineages of influenza B viruses have circulated globally since 1985. However, licensed trivalent seasonal influenza vaccines contain antigens from only a single influenza B virus and thus provide limited immunity against circulating influenza B strains of the lineage not present in the vaccine. In recent years, predictions about which B lineage will predominate in an ...

Rationale for Group a Streptococcal Vaccines

RATIONALE FOR GROUP A STREPTOCOCCAL VACCINES vaccines against Streptococcus pyogenes (the Lancefield group a streptococcus [Gas]) have been a goal of researchers and public health authorities since the beginning of the last century. the desire for an effective vaccine arises from the large burden of disease caused by the bacterium, particularly rheumatic fever and rheumatic heart disease. rheum...

Design Challenges for HIV-1 Vaccines Based on Humoral Immunity

INTRODUCTION Human Immunodeficiency Virus-1 (HIV1) presents profound challenges to vaccine developers. Potential hurdles of relevance to the design of an effective HIV-1 vaccine based on humoral immunity include: (1) the exceptional rate of mutation of the viral genome due to an error-prone polymerase (i.e., reverse transcriptase) (1), (2) a relatively high rate of genomic recombination (2, 3),...

Prospects for vaccines against HIV.

Design Rationale for Software Maintenance

For a number of years, members of the Artificial Intelligence (AI) in Design community have studied Design Rationale (DR), the reasons behind decisions made while designing. A record of what decisions were made, and why, is especially valuable for software maintenance. One reason for this is that the software lifecycle is a long one. Large projects may take years to complete and spend even more...